The Wests Tigers have burst out of the blocks thanks to a pair of rookies and they lead the Rabbitohs 10-4 in the first half.
Charlie Staines scored the opener before Tigers teenagers Laclan Galvin and Luke Laulilii combined for the second.
The smallest man in the NRL, Jye Gray, scored for Souths when he pounced on an offload from Taane Milne in the 15th minute.
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MATCH CENTRE: Wests Tigers v Rabbitohs, video, teams, stats
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MATCH PREVIEW
Wests Tigers coach Benji Marshall has replaced star rookie Jahrome Bula with another exciting young gun Heath Mason for this clash against the Rabbitohs.
Bula is out for the season but his shoulder injury has paved the way for 18-year-old Mason to make his first NRL start.
Tigers winger Luke Laulilii replaces Solomon Alaimalo (concussion) while Alex Seyfarth replaces Reuben Porter as Sione Fainu joins the bench.
Souths interim coach Ben Hornby has been forced to make just one change this week with Tallis Duncan replacing Michael Chee Kam (calf) in the back row.
Jacob Host also joins the bench while Cameron Murray and Keaon Koloamatangi have swapped places between back row and lock.
Hammer and Foxx on THAT foot race! | 01:39
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